Il-3 variant hematopoiesis fusion protein

Details Il-3 variant hematopoiesis fusion protein Il-3 variant hematopoiesis fusion protein

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/16 (2006.01) A61K 38/20 (2006.01) C07K 14/535 (2006.01) C07K 14/54 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2182483

The present invention relates to fusion molecules composed of human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally joined to a second colony stimulating factor (CSF), cytokine, lymphokine, interleukin or IL-3 variant. These hIL-3 variants contain amino acid substitutions and may also have amino acid deletions at both the N- and C-termini. The invention also relates to pharmaceutical compositions containing the fusion molecules and methods for using them.

La présente invention concerne des molécules hybrides composées de protéines variantes ou mutantes (mutéines) d'interleukine 3 humaine unies fonctionnellement à un deuxième facteur de croissance cellulaire tel que la cytokine, la lymphokine, l'interleukine ou une variante de l'IL-3. Ces variantes d'interleukine 3 humaine présentent des substitutions d'acide aminé et peuvent également comporter des délétions d'acide aminé à leur extrémité N-terminale et à leur extrémité C-terminale. L'invention porte également sur des compositions pharmaceutiques renfermant ces molécules hybrides et sur leur mode d'utilisation.

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