(imidazol-1-yl-methyl)-pyridazine as nmda receptor blocker

Details (imidazol-1-yl-methyl)-pyridazine as nmda receptor blocker (imidazol-1-yl-methyl)-pyridazine as nmda receptor blocker

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/505 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2485926

The present invention relates to compounds of formula (I) wherein A is an unsubstituted cyclic group; and R is hydrogen or lower alkyl; and pharmaceutically acceptable acid addition salts thereof. It has been shown that the compounds of formulas IA and IB are good NMDA NR-2B receptor subtype specific blockers. Possible therapeutic indications for these compounds include acute forms of neurodegeneration caused, e.g., by stroke and brain trauma, and chronic forms of neurodegeneration such as Alzheimer's disease, Parkinson's disease, Huntington's disease, ALS(amyotrophic lateral sclerosis) and neurodegeneration associated with bacterial or viral infections and, in addition, depression and chronic and acute pain.

Composés de formule (IA) ou (IB) dans lesquelles A représente un groupe cyclique non substitué et R représente hydrogène ou alkyle inférieur et sels d'addition d'acide pharmaceutiquement acceptables desdits composés. Il a été démontré que les composés des formules IA et IB sont de bons antagonistes du sous-type du récepteur NMDA NR-2B. Les indications thérapeutiques possibles pour ces composés comportent les formes aiguës de neurodégénérescence causées, par ex., par l'accident vasculaire cérébral et le traumatisme cérébral, et les formes chroniques de neurodégénérescence telles que la maladie d'Alzheimer, la maladie de Parkinson, la chorée de Huntington, et la sclérose latérale amyotrophique et la neurodégénérescence associée à des infections bactériennes ou virales ainsi, en outre, que la dépression et la douleur aiguë et chronique.

Affiliated with

Also associated with

Rating

(imidazol-1-yl-methyl)-pyridazine as nmda receptor blocker does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with (imidazol-1-yl-methyl)-pyridazine as nmda receptor blocker, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (imidazol-1-yl-methyl)-pyridazine as nmda receptor blocker will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1426692