Imidazol-4-yl-ethynyl-pyridine derivatives

Details Imidazol-4-yl-ethynyl-pyridine derivatives Imidazol-4-yl-ethynyl-pyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/4178 (2006.01) A61K 31/4439 (2006.01) A61P 25/00 (2006.01) A61P 25/22 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2516682

4-[1-Aryl-imidazol-4-ylethynyl]-2-alkyl-pyridine and 1-heteroaryl--imidazol-4-ylethynyl]-2-alkyl-pyridine derivatives and pharmaceutically acceptable salts thereof for the treatment or prevention of disorders mediated full or in part by metabotropic glutamate receptor 5, e.g. acute, traumatic and chronic degenerative processes of the nervous system, such as Alzheimer's disease, senile dementia, Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis and multiple sclerosis, psychiatric diseases such as schizophrenia and anxiety, depression, pain and drug dependency. (see formula I)

L'invention concerne des dérivés de la 4-[1-aryl-imidazol-4-yléthynyl]-2-alkyl-pyridine et de la 1-hétéroaryl-imidazol-4-yléthynyl]-2-alkyl-pyridine, ainsi que les sels pharmaceutiquement acceptables de ceux-ci, pour le traitement ou la prévention de troubles occasionnés, en totalité ou en partie, par le récepteur 5 du glutamate métabotropique, par exemple, processus aigus, traumatiques, et de dégénérescence chronique du système nerveux, tels que maladie d'Alzheimer, démence sénile, maladie de Parkinson, chorée de Huntington, sclérose latérale amyotrophique, sclérose en plaques, maladies psychiatriques, telles que schizophrénie et anxiété, dépression, douleur et toxicomanie.

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