Imidazole derivates as anti-inflammatory agents

Details Imidazole derivates as anti-inflammatory agents Imidazole derivates as anti-inflammatory agents

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4168 (2006.01) A61K 31/4184 (2006.01) A61K 31/437 (2006.01) A61K 31/454 (2006.01) A61K 31/5355 (2006.01) A61K 31/5377 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 235/30 (2006.01) C07D 401/06 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2458533

Compounds of formula (I): (see formula I) where R1, R2, Y, Z1 and Z2 are as defined herein, and pharmaceutical compositions thereof are provided that are useful in the treatment of inflammatory and immune- related conditions or disorders. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation.

L'invention concerne des composés (I) et des compositions pharmaceutiques contenant ceux-ci, utiles dans le traitement d'affections ou de troubles inflammatoires et associés au système immunitaire. Elle concerne en particulier des composés qui modulent l'expression et/ou la fonction de protéines intervenant dans l'inflammation, la régulation des réactions immunitaires et la prolifération cellulaire. Toutes les définitions sont décrites dans la demande.

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