C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/22 (2006.01) A61K 31/4164 (2006.01) A61K 31/4178 (2006.01) A61P 35/00 (2006.01) C07D 235/12 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 401/14 (2006.01) C07D 409/10 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/10 (2006.01)
Patent
CA 2759083
The invention provides compounds of the formula (I): and salts, tautomers, solvates and N-oxides thereof; wherein Q is CH or N; X is N, N+-O- or CR3; Y is N, N+-O- or CR3a; R1 and R2 are independently selected from hydrogen and various substituents as defined in the claims; or R1 and R2 together with the atoms to which they are attached, link to form an optionally substituted carbocyclic or heterocyclic aromatic or non-aromatic ring of 4 to 7 members; R3 is selected from hydrogen and various substituents; and R3a is selected from hydrogen and various substituents as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds. The compounds of formula (I) have activity as inhibitors of CDK kinases and are useful in the treatment of inter alia proliferative diseases such as cancers.
L'invention porte sur des composés de la formule (I) : et sur des sels, tautomères, solvates et N-oxydes de ceux-ci; dans laquelle Q représente CH ou N; X représente N, N+-O- ou CR3; Y représente N, N+-O- ou CR3a; R1 et R2 sont indépendamment choisis parmi l'hydrogène et divers substituants tels que définis dans les revendications; ou R1 et R2 conjointement avec les atomes auxquels ils sont attachés, se lient pour former un noyau aromatique ou non aromatique carbocyclique ou hétérocyclique facultativement substitué, ayant 4 à 7 chaînons; R3 est choisi parmi l'hydrogène et divers substituants; et R3a est choisi parmi l'hydrogène et divers substituants tels que définis dans les revendications. L'invention porte également sur des compositions pharmaceutiques contenant les composés de formule (I), sur des procédés de fabrication des composés et sur les utilisations médicales des composés. Les composés de formule (I) ont une activité comme inhibiteurs des CDK kinases et sont utiles dans le traitement entre autres de maladies prolifératives telles que les cancers.
Brain Christopher Thomas
Chen Christine Hiu-Tung
Chessari Gianni
Cho Young Shin
Congreve Miles Stuart
Fetherstonhaugh & Co.
Novartis Ag
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