Imidazole derivatives as ccr2 receptor antagonists

Details Imidazole derivatives as ccr2 receptor antagonists Imidazole derivatives as ccr2 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/4178 (2006.01) A61K 31/4439 (2006.01) A61P 9/00 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2691662

The invention is concerned with novel imidazole derivatives of formula (I), wherein (Ia), m, E, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR- 2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.

L'invention concerne de nouveaux dérivés imidazolés de formule (I), dans laquelle m, E, R1, R2, R3, R4, R5, R6 et R7 sont tels que définis dans la description et dans les revendications, ainsi que des sels physiologiquement acceptables desdits dérivés. Ces composés sont des antagonistes du récepteur CCR-2, du récepteur CCR-5 et/ou du récepteur CCR-3 et peuvent être utilisés comme médicaments.

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