Imidazopyrazine tyrosine kinase inhibitors

Details Imidazopyrazine tyrosine kinase inhibitors Imidazopyrazine tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 1/04 (2006.01) A61P 11/06 (2006.01) A61P 17/04 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2542481

Compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein Q1 and R1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.

L'invention concerne des composés de formule (I) et leurs sels pharmaceutiquement acceptables, formule dans laquelle Q?1 ¿et? ¿R?1¿ sont définis dans la description. Ces composés et ces sels inhibent l'enzyme IGF-1R et sont utiles pour le traitement et/ou la prévention de différentes maladies et états pathologiques qui réagissent à un traitement par inhibition des tyrosine kinases.

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