Imidazopyrazines as protein kinase inhibitors

Details Imidazopyrazines as protein kinase inhibitors Imidazopyrazines as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2710929

In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or Aurora kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or Aurora kinases using such compounds or pharmaceutical compositions.

La présente invention concerne, dans ses nombreux modes de réalisation, une nouvelle classe de composés d'imidazopyrazine comme inhibiteurs de protéines et/ou Aurora kinases, des procédés de préparation de tels composés, des compositions pharmaceutiques comprenant un ou plusieurs de ces composés, des procédés de préparation de formulations pharmaceutiques comprenant un ou plusieurs de ces composés et des procédés de traitement, de prévention, d'inhibition ou d'amélioration d'une ou de plusieurs maladies associées aux protéines ou Aurora kinases à l'aide de tels composés ou compositions pharmaceutiques.

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