Imidazopyridine derivatives inhibiting protein kinase...

Details Imidazopyridine derivatives inhibiting protein kinase... Imidazopyridine derivatives inhibiting protein kinase...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01)

Patent

CA 2637392

The inventive imidazopyridine derivative can be used in a pharmaceutical composition for preventing or treating diseases such as diabetes, obesity, dementia, cancer, and inflammation, since it can efficiently inhibit the activities of several protein kinases including glycogen synthase kinase-3 (GSK-3), aurora kinase, extracellular signal-regulated kinase (ERK), protein kinase B (AKT), and the likes, to control signal transductions thereof.

Le dérivé d'imidazopyridine selon l'invention peut être utilisé dans une composition pharmaceutique destinée à prévenir ou à traiter des maladies telles que le diabète, l'obésité, la démence, le cancer et l'inflammation, étant donné qu'il inhibe efficacement les activités de plusieurs protéines kinases, telles que la glycogène synthase kinase-3 (GSK-3), l'aurora kinase, la kinase régulée par un signal extracellulaire (ERK), la protéine kinase B (AKT), et analogues, afin de réguler les transductions de signaux desdites protéines kinases.

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