Imidazoylalkyl substituted with a five, six or seven...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/06 (2006.01) A61K 31/415 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 403/06 (2006.01)

Patent

CA 2309609

Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof. Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and an effective amount of a Compound of Formula (I). Further disclosed is a method of treating allergy (for example asthma), inflammation, hypotension, raised intraocular pressure (such as glaucoma) i.e., a method of lowering intraocular pressure, sleeping disorders, states of hyper and hypo motility and acidic secretion of the gastrointestinal tract, hypo and hyperactivity of the central nervous system (for example, agitation and depression) and other CNS disorders (such as Alzheimer's, Schizophrenia, obesity and migraine) comprising administering an effective amount of a compound of Formula (I) to a patient in need of such treatment. Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of Formula (I) in combination or admixture with a histamine H1 receptor antagonist.

L'invention concerne des composés de la formule (I) ou des sels ou solvates pharmaceutiquement acceptables desdits composés. On décrit des compositions pharmaceutiques comprenant un transporteur pharmaceutiquement acceptable et une quantité efficace d'un composé de la formule (I). On décrit également un procédé pour traiter une allergie (comme l'asthme), une inflammation, l'hypotension, une augmentation de la tension intraoculaire (telle que le glaucome), un procédé pour atténuer la tension intraoculaire, les troubles du sommeil, l'hyper ou hypomotilité et la sécrétion acide du tube digestif, l'hypo ou hyperactivité du système nerveux central (comme l'agitation ou la dépression), et d'autres troubles du SNC (comme la maladie d'Alzheimer, la schizophrénie, l'obésité ou la migraine). Le procédé consiste à administrer une quantité efficace d'un composé de la formule (I) à un patient nécessitant un tel traitement. On décrit enfin des procédés pour traiter des réactions allergiques de la voie aérienne supérieure, qui consistent à administrer un composé de la formule (I) ou un sel ou solvate dudit composé, en combinaison ou convenablement mélangé avec un antagoniste du récepteur H¿1? à l'histamine.

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