Immobilization of oligonucleotides onto solid supports

Details Immobilization of oligonucleotides onto solid supports Immobilization of oligonucleotides onto solid supports

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2445838

A solid support bound polynucleotide, preferably a 3'-O- or 5'-O-substituted polynucleotide, is disclosed. The polynucleotides are of formula: (I) wherein Q is a sustantially pure polynucleotide, each X is O or S; Y is an inert spacer group; R represents the solid support. Also disclosed is a method of isolating a target biomolecule, preferably a protein or a polynucleotide, from a mixture.

L'invention concerne un polynucléotide lié à un support solide, de préférence un polynucléotide substitué par 3'-<i>O</i>- ou par 5'-<i>O</i>-. Les polynucléotides selon l'invention sont représentés par la formule (I), dans laquelle Q représente un polynucléotide sensiblement pur ; chaque X représente O ou S ; Y représente un groupe d'espacement inerte ; R représente le support solide. L'invention concerne également une méthode permettant d'isoler une biomolécule cible, de préférence une protéine ou un polynucléotide, d'un mélange.

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