Immune-derived moieties reactive against lysophosphatidic acid

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/44 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2653931

Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1 -phosphate) in which a carbon atom has been derivatized with a pendant reactive group; immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead); monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen; and therapeutic and diagnostic compositions containing such antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described.

L'invention concerne des compositions et des procédés de production d'anticorps monoclonaux et de leurs dérivés réagissant contre des cibles lipidiques bioactives. Ces compositions contiennent des lipides dérivatisés contenant chacun un lipide bioactif ayant un groupe de tête polaire et au moins une chaîne hydrocarbonée (par ex. un lysolipide tel qu'un acide lysophosphatidique ou du sphingosine-1-phosphate) dans laquelle un atome de carbone a été dérivatisé avec un groupe réactif pendant; des immunogènes produits par liaison d'un lipide dérivatisé à une fraction porteuse (par ex. une protéine porteuse, du polyéthylène glycol, de l'or colloïdal, de l'alginate ou une bille de silicone); des anticorps monoclonaux et des dérivés produits par immunisation d'un animal avec un tel immunogène; et des compositions thérapeutiques et diagnostiques contenant de tels anticorps et dérivés d'anticorps. L'invention concerne également des procédés de production de tels lipides dérivatisés, d'immunogènes et d'anticorps et de dérivés d'anticorps monoclonaux, des procédés de détection de tels anticorps une fois produits, et des procédés thérapeutiques et diagnostiques d'utilisation de tels anticorps et de tels dérivés.

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