C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 38/00 (2006.01) A61K 47/00 (2006.01) C07K 14/47 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2693277
The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved.
La présente invention concerne la régulation du système immunitaire et, en particulier, la découverte selon laquelle la molécule CLEC9a est un marqueur de cellules dendritiques capables de présenter des antigènes extracellulaires au moyen de CMH de classe I. Ceci les rend particulièrement appropriées à la génération de réponses de lymphocytes T cytotoxiques. L'invention porte sur des matériaux et des procédés destinés à la fois à induire des réponses immunitaires contre des antigènes cibles et à inhiber ou supprimer des réponses immunitaires non souhaitées dans lesquelles ces cellules sont impliquées.
Joffre Olivier Pierre
Pennington Daniel
Reis E. Sousa Caetano
Rogers Neil Charles
Sancho-Madrid David
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cancer Research Technology Limited
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