Immunogenic complexes, preparation method thereof and use of...

Details Immunogenic complexes, preparation method thereof and use of... Immunogenic complexes, preparation method thereof and use of...

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01)

Patent

CA 2574340

The invention relates to a method of improving the immunogenicity of an immunogen, antigen or hapten, by means of coupling with a small support peptide. More specifically, the invention relates to a method of preparing an immunogenic complex, as well as the complexes that can be obtained using one such method, and to the use of said complexes as a medicament in order to increase the immunogenicity of an immunogen. The invention comprises, for example, a support peptide which is coupled with a peptide from protein G of the respiratory syncytial virus (RSV) and to the use thereof as a vaccine for the treatment of respiratory infections linked to RSV.

La présente invention concerne un procédé permettant d'améliorer l'immunogénicité d'un immunogène, antigène ou haptène, par couplage avec un peptide support de petite taille. Plus particulièrement, la présente invention concerne un procédé de préparation d'un complexe immunogène ainsi que les complexes susceptibles d'être obtenus par un tel procédé, et l'utilisation de tels complexes à titre de médicament pour augmenter l'immunogénicité d'un immunogène. L'invention comprend notamment un peptide support couplé avec un peptide issu de la protéine G du Virus Respiratoire Syncytial (VRS) et son utilisation à titre vaccinal pour le traitement des infections respiratoires liées au VRS.

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