Immunogenic compositions for chlamydia trachomatis

A - Human Necessities – 61 – K

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A61K 39/118 (2006.01) A61K 39/40 (2006.01)

Patent

CA 2526106

The invention relates to compositions comprising combinations of Chlamydia trachomatis antigens and their use in vaccines. Specific combinations may be selected from a first antigen group of PepA, LcrE, ArtJ, DnaK, and CT398, and a second antigen group of PepA, LcrE, ArtJ, DnaK, CT398, OmpH-like, L7/L12, OmcA, AtoS, CT547, Eno, HtrA and MurG. The invention further relates to the use of combinations of adjuvants for use with antigens associated with a sexually transmissible disease, such as Chlamydia trachomatis antigens. Preferred adjuvant combinations include mineral salts, such as aluminium salts and oligonucleotides comprising a CpG motif.

L'invention concerne des compositions comprenant des combinaisons d'antigènes de Chlamydia trachomatis et leur utilisation dans des vaccins. Des combinaisons spécifiques peuvent être sélectionnées à partir d'un premier groupe d'antigènes, constitué de PepA, LcrE, ArtJ, DnaK et CT398, et d'un second groupe d'antigènes, constitué de PepA, LcrE, ArtJ, DnaK, CT398, protéines analogues à celles de la membrane extérieure H (OmpH-like), L7/L12, OmcA, AtoS, CT547, Eno, HtrA et MurG. L'invention concerne également l'utilisation de combinaisons d'adjuvants destinées à être utilisées avec des antigènes associés à une maladie sexuellement transmissible, tels que les antigènes de Chlamydia trachomatis. Des combinaisons d'adjuvants préférées comprennent des sels minéraux, tels que des sels d'aluminium, et des oligonucléotides comprenant un motif CpG.

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