Immunogenic reagents from west nile virus

Details Immunogenic reagents from west nile virus Immunogenic reagents from west nile virus

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 39/12 (2006.01) A61K 39/295 (2006.01) C07K 14/005 (2006.01) C07K 14/18 (2006.01) C07K 16/08 (2006.01) C12N 1/06 (2006.01) C12Q 1/70 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2526640

Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.

L'invention concerne la production recombinante de protéines du virus Nil occidental immunogènes (VNO). Ces protéines, hétérodimères, comprennent leurs protéines, leurs fusions, les polynucléotides codant les protéines et leurs combinaisons ainsi que des anticorps obtenus à partir des éléments précités et que l'on peut utiliser dans des compositions immunogènes en vue de la prévention, du traitement et du diagnostic d'infections par VNO. L'invention concerne également des méthodes immunosérologiques à bande et ELISA très sensibles permettant de détecter la présence de VNO dans des échantillons biologiques.

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