Immunogens from uropathogenic escherichia coli

Details Immunogens from uropathogenic escherichia coli Immunogens from uropathogenic escherichia coli

C - Chemistry, Metallurgy

07

K

C07K 14/245 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2659552

Disclosed herein are various polypeptides that can be included in immunogenic compositions specific for pathogenic E. coli strains. The polypeptides have cellular locations which render them accessible to the immune system. The genes encoding the polypeptides were initially identified as being present in uropathogenic strain 536 but absent from non-pathogenic strains.

L'invention concerne différents polypeptides pouvant être incorporés dans des compositions immunogènes, spécifiques de souches pathogènes de E. coli. Les polypeptides ont des emplacements cellulaires qui les rendent accessibles au système immunitaire. Les gènes codant les polypeptides sont initialement identifiés comme étant présents dans la souche uropathogène 536, mais absents des souches non pathogènes.

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