B - Operations – Transporting – 01 – J
Patent
B - Operations, Transporting
01
J
182/11, 167/207
B01J 20/32 (2006.01) A61M 1/36 (2006.01) G01N 33/543 (2006.01) G01N 33/552 (2006.01) G01N 33/564 (2006.01)
Patent
CA 1261266
ABSTRACT OF THE DISCLOSURE . For the treatment of various diseases including autoimmune diseases such as myathenia gravis, articular rheumatism, lupus erythematosus, etc., immunity-related diseases such as glumerulonephritis, bronchial asthma, polyneuritis, etc., organ transplantation such as transplanted kidney rejection, AOB incompatibibity bone marrow transplantation, etc., tumor, hypertension, and hepatic insufficiency, immunoglobulin adsorbents comprising a hydroxyl-containing water insoluble carrier to which a diamine compound having the general formula: NH2(CH2)nNH2 wherein n is an integer having a value of 3 to 9 is attached through a silane coupling agent or a derivative thereof, to which diamine a heterocyclic compound is attached through a difunctional reagent, are useful as they can selectively and efficiently adsorb specific proteins such as immunoglobulins and immune complexes which are pathogenic substances in the diseases, exhibit minimized non-specific adsorption, and are safe and easy to sterilize.
505947
Sameshima Tadashi
Yamamoto Yuichi
Macrae & Co.
Terumo Kabushiki Kaisha Trading As Terumo Corporation
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