Immunoglobulin derivatives and process for the preparation...

Details Immunoglobulin derivatives and process for the preparation... Immunoglobulin derivatives and process for the preparation...

C - Chemistry, Metallurgy

07

K

530/15.06

C07K 16/06 (2006.01)

Patent

CA 1041997

ABSTRACT OF THE DISCLOSURE Novel immunoglobulin derivatives which are characterized in that in which the interchain disulfide bonds of immunoglobulin are predominantly cleaved, on the average 3 to 5 of the interchain disulfide bonds or the inter- and intra-chain disulfide bonds being cleaved, and so produced sulfur atoms (S-) are S-sulfonated (-S-SO3). The above immunoglobulin derivatives are prepared by reacting native immunoglobulin with (A) a compound capable of forming tetrathionate ion, and (B) a compound capable of forming in water, sulfite ion whereby cleaving on the average 3 to 5 inter-chain disulfide bonds, or inter- and intra-chain disulfide bonds, of the native immunoglobulin, and S-sulfonating (S-SO3) the so formed sulfur atoms. This invention also provides a water-soluble composition for injection containing said immuno- globulin derivative having the titre of anti-diphtheria of at least 1.0 I.U./ ml at its concentration of 10.0% by weight, and a pharmaceutically-acceptable solubilizing agent for said immunoglobulin derivative.

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