Immunostimulatory g,u-containing oligoribonucleotides

Details Immunostimulatory g,u-containing oligoribonucleotides Immunostimulatory g,u-containing oligoribonucleotides

A - Human Necessities

61

K

A61K 31/7105 (2006.01) A61K 31/205 (2006.01) A61K 31/7088 (2006.01) A61K 31/7115 (2006.01) A61K 31/712 (2006.01) A61K 31/7125 (2006.01) A61K 31/713 (2006.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61P 37/04 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2480775

Compositions and methods relating to immunostimulatory RNA oligomers are provided. The immunostimulatory RNA molecules are believed to represent natural ligands of one or more Toll-like receptors, including Toll-like receptor 7 (TLR7) and Toll-like receptor 8 (TLR8). The compositions and methods are useful for stimulating immune activation. Methods useful for screening candidate immunostimulatory compounds are also provided.

La présente invention concerne des compositions et des méthodes se rapportant à des oligomères d'ARN immunostimulant. Les molécules d'ARN immunostimulant sont censées représenter des ligands naturels d'un ou de plusieurs récepteurs de type Toll, notamment du récepteur 7 de type Toll (TLR7) et du récepteur 8 de type Toll (TLR8). Lesdites compositions et méthodes sont utiles pour stimuler l'activation immunitaire. L'invention concerne également des méthodes utiles pour cribler des composés immunostimulants candidats.

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