Immunosuppressive polypeptides and nucleic acids

Details Immunosuppressive polypeptides and nucleic acids Immunosuppressive polypeptides and nucleic acids

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 37/06 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2703263

The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.

L'invention porte sur des polypeptides immunosuppresseur et sur des acides nucléiques codant pour de tels polypeptides. Sous un aspect, l'invention porte sur des polypeptides CTLA-4 mutants et sur des acides nucléiques codant pour polypeptides CTLA-4 mutants. L'invention porte également sur des compositions et des procédés pour utiliser de tels polypeptides et acides nucléiques.

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