C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 35/14 (2006.01) A61P 37/02 (2006.01) C07K 7/04 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2436903
A peptide comprising an HLA-binding peptide of human CD45 polypeptide or a portion or variant of said peptide provided that the peptide is nothe intact human CD45 polypeptide. Preferably, the peptide comprises the amino acid sequence FLYDVIAST or ALIAFLAFL or KLFTAKLNV or MIWEQKATV or NLSELHPYL or VNLSELHPYL or LLAFGAFAFL or YLYNKETKL or LILDVPPGV or TLILDVPPGB or ILYNNHKFT or ILPYDYNRV or YILIHQALV or FQLHDCTQV or KLLAFGFAFL or YQYQYTNWSV or a portion or variant of any of these. Methods of leukaemia immunotherpay using specific cytotoxic T lymphocytes are also disclosed.
La présente invention concerne un peptide de liaison HLA du polypeptide CD45 humain ou un fragment ou une variante dudit peptide, ledit peptide ne correspondant pas au polypeptide CD45 humain intact. De préférence, le peptide comprend une séquence d'acides aminés FLYDVIAST ou ALIAFLAFL ou KLFTAKLNV ou MIWEQKATV ou NLSELHPYL ou VNLSELHPYL ou LLAFGAFAFL ou YLYNKETKL ou LILVDPPGV ou TLILDVPPGV ou ILYNNHKFT ou ILPYDYNRV ou YILIHQALV ou FQLHDCTQV ou KLLAFGFAFL ou YQYQYTNWSV ou un fragment ou une variante de l'une quelconque de celles-ci. Cette invention concerne également des procédés permettant l'immunothérapie de la leucémie par utilisation de lymphocytes T cytotoxiques spécifiques.
Amrolia Persis J.
Stauss Hans Josef
Borden Ladner Gervais Llp
Imperial College Innovations Limited
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