Improved method for the preparation of an aspartame-derived...

Details Improved method for the preparation of an aspartame-derived... Improved method for the preparation of an aspartame-derived...

C - Chemistry, Metallurgy

07

K

C07K 5/075 (2006.01) C07K 5/072 (2006.01)

Patent

CA 2187901

Method and preparation of N-[N-(3,3,-dimethylbutyl)-L-.alpha.-aspartyl]-L- phenylalanine 1-methyl ester of formula (I), useful as a sweetener. The method is characterized in that a hydroalcohol solution comprising aspartame and 3,3-dimethylbutyraldehyde and having a pH of 4.5-5 is treated with hydrogen at ambient temperature and at a pressure not exceeding 1 bar in the presence of a catalyst selected from the group consisting of platinum or palladium on activated carbon, or platinum black or palladium black, and in that the produit is purified by precipitation and filtration after the alcohol part of the solvent is eliminated by the use of a vacuum.

Procédé de préparation du N-[N-(3,3-diméthylbutyl)-L- alpha -aspartyl]-L-phénylalanine 1-méthyl ester de formule (I), utile comme agent édulcorant, procédé caractérisé en ce que l'on traite une solution hydroalcoolique de pH 4,5-5 d'aspartame et de 3,3-diméthylbutyraldéhyde à température ambiante par de l'hydrogène à une pression inférieure ou égale à 1 bar en présence d'un catalyseur choisi dans le groupe comprenant le platine ou le palladium sur carbone activé, ou sous forme de noir de platine ou de palladium, et en ce que le produit formé est purifié par précipitation et filtration après élimination sous vide de la partie alcoolique du solvant.

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