Improved oxidation process with enhanced safety useful in...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 493/22 (2006.01)

Patent

CA 2650983

The present invention provides a safe and effective process for the selective oxidation with stabilised 2-iodoxybenzoic of a 5-O-protected-LLF-28249-.alpha. compound to the corresponding 23-keto compound of formula (I), wherein R is a protecting group. The present invention also provides the use of the selective oxidation process in the manufacture of moxidectin.

La présente invention concerne un procédé sûr et efficace d'oxydation sélective d'un composé 5-O-protégé-LLF-28249-a pour obtenir le composé 23-cétone correspondant de formule (I), R étant un groupe de protection. La présente invention concerne également l'utilisation du procédé d'oxydation sélective dans la fabrication de moxidectine.

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