Improved polysaccharide and glycoconjugate vaccines

Details Improved polysaccharide and glycoconjugate vaccines Improved polysaccharide and glycoconjugate vaccines

A - Human Necessities

61

K

A61K 39/02 (2006.01) A61K 39/095 (2006.01) A61K 39/385 (2006.01) C07K 1/107 (2006.01) C07K 14/22 (2006.01) C07K 17/06 (2006.01) C07K 17/10 (2006.01)

Patent

CA 2484279

The present invention concerns a conjugation process for coupling a endotoxin (LPS) free polyfunctional polysaccharide with a polyfunctional carrier protein with quantitative yields. The invention also provides for vaccine formulations comprising the glyconjugate antigen manufactured by the process.

L'invention concerne un procédé de conjugaison pour coupler une endotoxine (LPS) sans polysaccharide polyfonctionnelle avec une protéine excipient polyfonctionnelle ayant des rendements quantitatifs. L'invention concerne également des formulations de vaccins comprenant l'antigène glyconjugué obtenu à partir de ce procédé.

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