Improved quenching methods for red blood cell inactivation...

A - Human Necessities – 61 – L

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A61L 2/16 (2006.01) C07K 5/02 (2006.01)

Patent

CA 2585621

Methods are provided for improved quenching of undesired side reactions upon treating a red blood cell composition with a pathogen inactivating compound comprising a nucleic acid binding ligand and a functional group which is, or which is capable of forming, an electrophilic group. In some embodiments, the improved methods use a suitably high concentration of quencher that comprises a nucleophilic functional group that is capable of covalently reacting with the electrophilic group, wherein the treatment occurs within a desired pH range to provide sufficient quenching. Preferred quenchers for use in some of the methods include thiols, such as glutathione, which have been suitably neutralized such that addition to a red blood cell composition results in the desired concentration of quencher at a desirable pH range of 6.8 to 8.5.

L'invention concerne des procédés d'inhibition améliorés de réactions secondaires indésirables par traitement d'une composition de globules rouges avec un composé d'inactivation pathogène contenant un ligand liant un acide nucléique et un groupe fonctionnel formant ou pouvant former un groupe électrophile. Dans certains modes de réalisation, les procédés améliorés utilisent une concentration de l'inhibiteur suffisamment élevée comportant un groupe fonctionnel nucléophile capable de réagir par covalence avec le groupe électrophile, le traitement apparaissant avec une plage de pH souhaitée pour obtenir une inhibition suffisante. Des inhibiteurs préférés à utiliser dans certains procédés contiennent des thiols, tels que des glutathions qui sont été neutralisés de manière adéquate telle que l'addition à une composition de globules rouges permettant d'obtenir la concentration de l'inhibuteur souhaitée à une plage de pH souhaitée entre 6,8 et 8,5.

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