A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2561835
Disclosed is a method for improving cancer therapy that relies on induction of apoptosis in malignant cells. It has been found that docking of protease inhibitors PAI-1 and TIMP-1 renders malignant cells expressing these inhibitors more sensitive to apoptosis, whereas non~-malignant cells do not change their sensitivity to apoptosis induction. It is therefore possible to increase the effect of various anti-cancer treatments in a rational manner and to predict whether or not an apoptosis-inducing cancer treatment will be effective in a patient or not. The invention also provides for methods of identifying agents that inhibit the apoptosis sensitivity modulating effects of protease inhibitors and to methods of identifying anti-cancer compounds that are not dependent on an apoptosis inducing mechanism which can be modulated by protease inhibitors.
La présente invention a trait pour l'amélioration de la thérapie du cancer qui repose sur l'induction de l'apoptose dans des cellules malignes. Il a été démontré que le blocage d'inhibiteurs de la protéase PAI-1 et TIMP-1 rend les cellules malignes exprimant ces inhibiteurs plus sensibles à l'apoptose, tandis que des cellules non malignes ne modifient pas leur sensibilité à l'induction de l'apoptose. Il est donc possible d'accroître l'effet de divers traitements anticancéreux de manière rationnelle et de prédire si un traitement du cancer induisant l'apoptose sera efficace chez un patient ou non. L'invention a également trait à des procédés permettant l'identification d'agents inhibiteurs des effets modulateurs de la sensibilité à l'apoptose d'inhibiteurs de la protéase et à des procédés d'identification de composés anticancéreux qui ne dépendent pas d'un mécanisme d'induction de l'apoptose pouvant être modulé par des inhibiteurs de la protéase.
Brunner Nils Age
Foekens Johannes Albert
Hofland Kenneth Francis
Jensen Peter Buhl
Lademann Ulrik Axel
Den Kgl. Veterinaer-Og Landbohojskole
Gowling Lafleur Henderson Llp
Rigshospitalet
University Of Copenhagen
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