C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/32 (2006.01) A61K 31/445 (2006.01) C07C 225/18 (2006.01) G01N 30/02 (2006.01) G01N 30/90 (2006.01) G01N 33/15 (2006.01)
Patent
CA 2653538
The present invention relates to impurities of donepezil, or a pharmaceutically acceptable salt thereof, which may be produced during synthesis and storage of donepezil, or a pharmaceutically-acceptable salt thereof, and to methods of identifying such impurities.The invention also relates to the use of these impurities in analytical techniques and to product that contain certain low levels of these impurities in particular the following impurities are disclosed: formula (I) and formula (II).
La présente invention concerne des impuretés du donépézil ou de l'un de ses sels pharmaceutiquement acceptables, lesdites impuretés pouvant être produites pendant la synthèse et le stockage du donépézil ou de son sel pharmaceutiquement acceptable. L'invention concerne également des procédés permettant d'identifier de telles impuretés et l'utilisation desdites impuretés dans le cadre de techniques analytiques, ainsi que des produits contenant des teneurs faibles de ces impuretés, notamment les impuretés suivantes :
Dogan Koruznjak Jasna
Grebenar Ivica
Kaczorowska Katarzyna
Krizmanic Irena
Lerman Lidija
Borden Ladner Gervais Llp
Pliva Hrvatska D.o.o.
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