Inclusion complexes of n-ethoxycarbonyl-3-morpholino-...

Details Inclusion complexes of n-ethoxycarbonyl-3-morpholino-... Inclusion complexes of n-ethoxycarbonyl-3-morpholino-...

C - Chemistry, Metallurgy

08

B

C08B 37/16 (2006.01) A61K 47/40 (2006.01) C07D 271/04 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2054188

The invention relates to inclusion complexes of N- ethoxycarbonyl-3-morpholino-sydnonimine or its salts formed with a cyclodextrin derivatives, preparation thereof and pharmaceutical compositions containing the same. The inclusion complex of N-ethoxycarbonyl-3- morpholino-sydnonimine or its salt formed with cyclo- dextrin derivative is prepared by a) reacting the N-ethoxycarbonyl-3-morpholino- sydnonimine or its salt and the cyclodextrin derivative in a solvent medium, and if desired recovering the complex from the solution by dehydratation, or b) high energy milling of the N-ethoxycarbonyl-3- morpholino-sydnonimine or its salt and the cyclodextrin derivative.

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