Indan derivatives and process for preparation thereof

Details Indan derivatives and process for preparation thereof Indan derivatives and process for preparation thereof

C - Chemistry, Metallurgy

07

C

167/179, 260/312

C07C 311/20 (2006.01) C07C 233/52 (2006.01) C07C 311/29 (2006.01) C07D 257/06 (2006.01) C07D 333/34 (2006.01) C07D 333/36 (2006.01)

Patent

CA 1331462

- 1 - Abstract: Indan derivatives of the formula: (I) Image wherein R1 is substituted or unsubstituted phenyl, naphthyl or sulfur-containing heterocyclic group, and R2 is hydroxy- methyl or a group of the formula: Image wherein R3 is a hydrogen atom or lower alkyl and R4 is cycloalkyl, lower alkoxycarbonyl-phenyl, carboxy-phenyl, nitrogen-containing heterocyclic group, lower alkyl, or lower alkyl having a substituent selected from lower alkoxycarbonyl, carboxy, lower alkoxycarbonyl-phenyl, carboxy-phenyl, lower alkoxy- carbonyl-cycloalkyl and carboxy-cycloalkyl, or a pharma- ceutically acceptable salt thereof, which are useful as platelet aggregation-inhibiting agents and as agents for the treatment, amelioration and/or prophylaxis of a variety of thrombosis or embolism, coronary and cerebral vascular smooth muscle vellication, asthma, and the like, processes for the preparation thereof, and a pharmaceutical composition containing said compound as an active ingredient.

583351

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