Indene derivatives and process for the preparation thereof

Details Indene derivatives and process for the preparation thereof Indene derivatives and process for the preparation thereof

C - Chemistry, Metallurgy

07

C

C07C 229/50 (2006.01) A61K 31/216 (2006.01) A61K 31/277 (2006.01) A61K 31/5375 (2006.01) A61P 3/00 (2006.01) A61P 11/00 (2006.01) A61P 35/00 (2006.01) C07C 69/757 (2006.01) C07C 231/00 (2006.01) C07C 233/52 (2006.01) C07C 255/47 (2006.01) C07D 295/088 (2006.01) C07D 295/155 (2006.01)

Patent

CA 2562951

The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.

Les dérivés indènes représentés par la formule (I) sont capables de moduler sélectivement les activités des récepteurs activés par les proliférateurs des péroxisomes ou "PPAR" (Peroxisome Proliferator Activated Receptors), sans effets secondaires. Ils conviennent donc particulièrement au traitement et à la prévention de troubles modulés par les PPAR, et notamment les syndromes métaboliques tels que le diabète, l'obésité, l'artériosclérose, l'hyperlipémie, l'hyperinsulinisme et l'hypertension, les affections inflammatoires telles que l'ostéoporose, la cirrhose du foie et l'asthme, et le cancer.

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