Indene derivatives and process for the preparation thereof

Details Indene derivatives and process for the preparation thereof Indene derivatives and process for the preparation thereof

C - Chemistry, Metallurgy

07

C

C07C 251/32 (2006.01) A61K 31/215 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/06 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01) C07C 45/28 (2006.01) C07C 45/61 (2006.01) C07C 249/08 (2006.01)

Patent

CA 2563000

The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer. (see formula I)

L'invention concerne des dérivés d'indène représentés par la formule (I). Ces dérivés sont capables de moduler sélectivement les activités des récepteurs PPAR (récepteurs activés de la prolifération des peroxysomes), sans causer d'effets secondaires défavorables et, par conséquent, ils sont utiles pour le traitement et la prévention de troubles modulés par PPAR, c'est-à-dire, les syndromes métaboliques, tels que le diabète, l'obésité, l'artériosclérose, l'hyperlipidémie, l'hyperinsulinisme et l'hypertension, les maladies inflammatoires, tels que l'ostéoporose, la cirrhose du foie et l'asthme et le cancer.

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