Indeno[1,2-c]pyrazole derivatives for inhibiting tyrosine...

Details Indeno[1,2-c]pyrazole derivatives for inhibiting tyrosine... Indeno[1,2-c]pyrazole derivatives for inhibiting tyrosine...

A - Human Necessities

61

K

A61K 31/415 (2006.01)

Patent

CA 2304466

Chemical compounds that are derivatives of indeno[1,2-c]pyrazole are inhibitors of tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell proliferation is a factor. Compounds of this invention also inhibit the induction of vascular hyperpermeability and the associated formation of edema, ascites, and exudates.

L'invention concerne des composés chimiques qui sont des dérivés d'indéno[1,2-c]pyrazole, et constituent des inhibiteurs de l'activité de tyrosine kinase. Plusieurs des tyrosine kinases dont l'activité est inhibée par ces composés chimiques jouent un rôle dans des processus d'angiogenèse. Par conséquent, ces composés chimiques peuvent améliorer des états pathologiques dans lesquels sont impliqués des facteurs d'angiogenèse ou de prolifération de cellules endothéliales. Des composés de l'invention permettent également d'inhiber un déclenchement d'hyperperméabilité vasculaire ainsi que la formation associée d'oedèmes, d'ascites et d'exsudats.

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