Indole derivatives

Details Indole derivatives Indole derivatives

C - Chemistry, Metallurgy

07

D

260/319.3

C07D 209/20 (2006.01) C07D 209/16 (2006.01)

Patent

CA 1281334

A B S T R A C T Indoles are disclosed of formula (I): Image (I) wherein R1 represents R5R6NCOCH2-, R5CONH(CH2)p-, R5R6NSO2(CH2)p- or R7SO2NH(CH2)p-, (where R5 and R6 each represents a hydrogen atom or a C1-3 alkyl group, R7 represents C1-3 alkyl and p is zero or one), R2 is hydrogen or C1-3 alkyl; R3 and R4 each represents hydrogen atom, C1-3 alkyl, or 2-propenyl; m is zero or an integer from 1 to 4; and n is an integer from 2 to 5; and physiologically acceptable salts and solvates (e.g. hydrates) thereof. The compounds have potent and selective vasoconstrictor activity and are indicated as useful for the treatment of migraine. They may be formulated as pharmaceutical compositions with pharmaceutically acceptable carriers or excipients for administration by any convenient route. Various methods for the preparation of the compounds (I) are disclosed.

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