Indole derivatives

Details Indole derivatives Indole derivatives

C - Chemistry, Metallurgy

07

D

C07D 209/10 (2006.01) A61K 31/395 (2006.01) C07D 209/12 (2006.01) C07D 209/14 (2006.01) C07D 209/18 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 405/06 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01)

Patent

CA 2042905

ABSTRACT Compounds of the formula: Image wherein R1 is carboxy or protected carboxy, R2 is hydrogen, lower alkyl or halogen R3 is aryl or ar(lower)alkyl, each of which may have suitable substituent(s), or a group of the formula: Image in which Image is heterocyclic group containing nitrogen atom, and n is 0 or 1, A is lower alkylene which may be substituted by oxo or lower alkenylene, Q is carbonyl or lower alkylene, Image or Image in which R4 is hydrogen or lower alkyl, and R5 is hydrogen, lower alkyl or Y-Z-R3, Y is bond or lower alkylene, Z is lower alkylene, -O- or Image , in which R6 is hydrogen, lower alkyl, ar(lower)alkyl which may have suitable substituent(s) or amino protective group, and pharmaceutically acceptable salts thereof. The process of producing these compounds, pharmaceutical compositions containing same, the treatment of testosteron 5.alpha.-reductase-mediated disease and the preparation of the compositions are also disclosed. The invention is useful for treating diseases such as alopecia, acnes, prostatism, and the like.

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