Indole derivatives and their use as inhibitors of p53-mdm2...

Details Indole derivatives and their use as inhibitors of p53-mdm2... Indole derivatives and their use as inhibitors of p53-mdm2...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) A61K 31/501 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 413/14 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2579915

The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, m, p, s, t, R1, R2, R3, R4, R5, R6, R7, X, Y, Q and Z have defined meanings.

La présente invention a pour objet des composés de formule (I), leur utilisation en tant qu~inhibiteurs d'une interaction entre les protéines p53 et MDM2, ainsi que des préparations pharmaceutiques comprenant lesdits composés de formule (I), où n, m, p, s, t, R1, R2, R3, R4, R5, R6, R7, X, Y, Q et Z ont des valeurs définies.

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