Indole derivatives comprising an acetylene group as ppar...

Details Indole derivatives comprising an acetylene group as ppar... Indole derivatives comprising an acetylene group as ppar...

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) A61K 31/405 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2576091

This invention is concerned with compounds of the formula (I), wherein one of R6, R7, R8 and R9 is formula (II), and X, R1 to R12, m, n and o are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR.delta. and/or PPAR.alpha. agonists.

L'invention concerne des composés correspondant à la formule (I), dans laquelle un des R6, R7, R8 et R9 correspond à la formule (II), et X, R1 à R12, m, n et o sont définis dans le descriptif, ainsi que leurs sels et/ou esters pharmaceutiquement acceptables. L'invention concerne des compositions pharmaceutiques contenant ces composés, un processus de leur préparation et de leur utilisation dans le traitement et/ou la prévention des maladies modulées par PPARd et/ou les agonistes de PPARa.

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