Indole derivatives, salts thereof, and heart affection...

Details Indole derivatives, salts thereof, and heart affection... Indole derivatives, salts thereof, and heart affection...

C - Chemistry, Metallurgy

07

D

C07D 491/048 (2006.01) A61K 31/395 (2006.01) A61K 31/695 (2006.01) C07D 491/04 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2134608

An indole derivative represented by formula (1), Image wherein A is a group Image wherein R10 is hydrogen or lower alkyl, dotted lines may optionally be present, and R1-R9 represents various substitutional groups. The compound. (1) exhibits a positive inotropic action on cardiac muscle, an anti- arrhythmic action, and a vasodilation action without increasing the heart rate. A heart affection therapeutic agent comprising this compound as an effective component is extremely effective for treating heart failures and arrhythmia.

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