C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/12 (2006.01) A61K 31/404 (2006.01) A61K 31/4045 (2006.01) A61P 35/00 (2006.01) C07D 209/34 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2493436
The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula (see formula I) in which X is oxygen; R1, R5 and R6 are hydrogen; R2 is halo or cyano; and R3 and R4 are optionally substituted phenyl, to their tautomers, enantiomers, diastereomers, to their mixtures and to their salts, in particular their physiologically acceptable salts, which have useful pharmacological properties, in particular in inhibiting action on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, to medicaments comprising these compounds, to their use and to processes for their preparation.
L'invention concerne des dérivés d'indolinone substitués en position 6, de formule générale (I), dans laquelle R¿1? à R¿6? et X ont la définition mentionnée dans la revendication (1), leurs tautomères, énantiomères, diastéréomères, leurs mélanges et leurs sels, notamment leurs sels physiologiquement acceptables, qui présentent des propriétés pharmacologiques intéressantes, notamment un effet inhibiteur sur différents récepteurs à tyrosine kinase, et sur la prolifération de cellules endothéliales et de différentes cellules tumorales. L'invention concerne également des médicaments contenant lesdits composés, l'utilisation de ces derniers et des procédés pour la préparation desdits composés.
Heckel Armin
Hilberg Frank
Kley Joerg
Lehmann-Lintz Thorsten
Roth Gerald Juergen
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Fetherstonhaugh & Co.
LandOfFree
Indolinone derivatives, substituted in the 6-position, their... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Indolinone derivatives, substituted in the 6-position, their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indolinone derivatives, substituted in the 6-position, their... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1420660