Indolinone hydrazides as c-met inhibitors

Details Indolinone hydrazides as c-met inhibitors Indolinone hydrazides as c-met inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01)

Patent

CA 2529622

The present invention relates to compounds of the formulae (I) - (XII), wherein R1 - R71, A, B, X, Y, G, L and Z are defined herein, and their pharmaceutically acceptable salts. These compounds modulate the activity of c- Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer.

L'invention se rapporte à des composés présentant les formules (I) à (XII) dans lesquelles R¿1? R¿71?, A, B, X, Y, G, L et Z sont tels que définis dans la description, ainsi qu'à leurs sels pharmaceutiquement acceptables. Les composés selon l'invention modulent l'activité du récepteur c-Met. Ainsi, ils peuvent, en toute logique, servir à prévenir et à traiter des troubles liés au récepteur c-Met tels que le cancer.

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