C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/34 (2006.01) A61K 31/404 (2006.01) A61P 43/00 (2006.01) C07D 209/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 487/08 (2006.01)
Patent
CA 2442695
The invention relates to indolinones, substituted in position 6, of general formula (I), in which R1 to R5 and X are defined as per claim (1). The invention also relates to their isomers and salts, in particular to their physiologically compatible salts, which have valuable pharmacological properties, specifically an inhibiting action on various receptor tyrosine kinases and cyclin/CDK complexes, in addition to on the proliferation of endothelium cells and various tumour cells. The invention further relates to medicaments containing said compounds, to the use of said medicaments and to a method for their production.
L'invention concerne des indolinones substituées en position 6, de formule générale (1), dans laquelle R¿1? à R¿5? et X sont tels que définis dans la revendication 1, leurs isomères et leurs sels, en particulier leurs sels physiologiquement compatibles présentant des propriétés pharmacologiques précieuses, notamment un effet inhibiteur sur différents récepteurs tyrosinekinases et complexes cycline/CDK, et sur la prolifération de cellules d'endothélium et de diverses cellules tumorales. L'invention concerne en outre des médicaments renfermant ces composés, leur utilisation et leur procédé de production.
Heckel Armin
Hilberg Frank
Kley Joerg
Lehmann-Lintz Thorsten
Roth Gerald Juergen
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Fetherstonhaugh & Co.
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