Indolizine acetic acid derivatives as crth2 antagonists

Details Indolizine acetic acid derivatives as crth2 antagonists Indolizine acetic acid derivatives as crth2 antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2681409

The specific compounds of this list : {7-cyano-2-methyl-1-[4-(morpholine-4-sutfonyl)benzyl]indolizin-3-yl}acetic acid, {1 -(3-chloro-4-ethanesulfonylbenzyl)-7-cyano-2-methylindolizin-3-yl}acetic acid, {1-[3-chloro4-(morpholine-4-sulfonyl)benzyl]-7-cyano-2-methylindolizin-3-yl}acetic acid, {1-(3-chloro-4-ethanesulfonylphenylsulfanyl)-7-cyano-2-methylindolizin-3-yl}acetic acid, {1-[3-chloro-4-(morpholine-4-sutfonyl)phenylsutfanyl]-7-cyano-2-methylindolizin-3- yl}acetic acid, {7-cyano-1 -(6-fluoroquinolin-2-y1methyl)-2-methylindolizin-3-yl}acetic acid are ligands of the CRTH2 receptor and are useful in the treatment of respiratory diseases.

L'invention concerne les composés spécifiques de la liste suivante : acide {7-cyano-2-méthyl-1-[4-(morpholine-4-sulfonyl)benzyl]indolizin-3-yl}acétique, acide {1 -(3-chloro-4-éthanesulfonylbenzyl)-7-cyano-2-méthylindolizin-3-yl}acétique, acide {1-[3-chloro4-(morpholine-4-sulfonyl)benzyl]-7-cyano-2-méthylindolizin-3-yl}acétique, acide {1-(3-chloro-4-éthanesulfonylphénylsulfanyl)-7-cyano-2-méthylindolizin-3-yl}acétique, acide {1-[3-chloro-4-(morpholine-4-sulfonyl)phénylsulfanyl]-7-cyano-2-méthylindolizin-3- yl}acétique, acide {7-cyano-1 -(6-fluoroquinolin-2-ylméthyl)-2-méthylindolizin-3-yl}acétique, lesdits composés étant des ligands du récepteur CRTh2 et se révélant utiles dans le traitement des maladies respiratoires.

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