Indolo ¬2',3',3,4| pyrido ¬2,1-b|, quinazoline-5- ones and a...

Details Indolo ¬2',3',3,4| pyrido ¬2,1-b|, quinazoline-5- ones and a... Indolo ¬2',3',3,4| pyrido ¬2,1-b|, quinazoline-5- ones and a...

C - Chemistry, Metallurgy

07

D

260/242.01

C07D 459/00 (2006.01) C07D 471/14 (2006.01)

Patent

CA 1168234

Abstract of the Disclosure The invention relates to new indolo[2',3',3,4]pyrido[2,1-b],quinazoline- S-ones of formula I Image (I) Image and the pharmaceutically acceptable salts thereof. In the formula R stands for hydrogen or C1-4 alkyl. Typical values for Rl, R2, R3, R4, R5 and R6 include hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, phenyl, cyano, C1-4 acyl, nitro, carboxy, C2-5 alkoxycarbonyl, amino and C1-4 acylamino. The compounds of formula I are substituted derivatives of Rutecarpine and, like Rutecarpine, are useful as diuretics and for influencing respiration and blood circulation.

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