C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/82 (2006.01) A61K 39/145 (2006.01) A61P 31/16 (2006.01) A61P 37/04 (2006.01) C07K 14/11 (2006.01) C12N 7/01 (2006.01) C12N 7/02 (2006.01) C12N 15/29 (2006.01) C12N 15/44 (2006.01)
Patent
CA 2693956
A method for synthesizing influenza virus--like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of influenza HA in plants and the purification by size exclusion chromatography. The invention is also directed towards a VLP comprising influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
L'invention porte sur un procédé de synthèse de pseudo-particules du virus de la grippe (VLP) dans une plante ou dans une partie de la plante. Le procédé met en jeu l'expression de la HA de la grippe dans des plantes et la purification par chromatographie d'exclusion stérique. L'invention se rapporte également à une VLP comprenant une protéine HA grippale et des lipides végétaux. L'invention porte enfin sur un acide nucléique codant pour une HA grippale ainsi que sur des vecteurs. Les VLP peuvent être utilisés pour formuler des vaccins contre la grippe ou enrichir des vaccins existants.
Couture Manon
D'aoust Marc-Andre
Dargis Michele
Landry Nathalie
Lavoie Pierre-Olivier
Gowling Lafleur Henderson Llp
Medicago Inc.
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