Inhalable epinephrine

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/12 (2006.01) A61K 9/14 (2006.01) A61K 31/19 (2006.01) A61K 31/195 (2006.01)

Patent

CA 2488976

The present invention is directed toward particles for delivery of epinephrine to the respiratory system and methods for treating a patient in need of epinephrine. The particles and respirable compositions comprising the particles of the present invention described herein comprise the bioactive agent epinephrine, or a salt thereof, as a therapeutic agent. The particles are preferably formed by spray drying. Preferably, the particles and the respirable compositions are substantially dry and are substantially free of propellents. In a preferred embodiment, the particles have aerodynamic characteristics that permit targeted delivery of epinephrine to the site(s) of action.

L'invention concerne des particules destinées à distribuer de l'épinéphrine au système respiratoire ainsi que des méthodes de traitement d'un patient qui a besoin d'épinéphrine. Lesdites particules et les compositions pouvant être respirées, comprenant lesdites particules comprennent l'agent bioactif épinéphrine ou un de ses sels, utilisé en tant qu'agent thérapeutique. Lesdites particules sont formées de préférence par séchage par pulvérisation. De préférence, les particules et les compositions pouvant être respirées sont sensiblement sèches et sont sensiblement exemptes d'agents propulseurs. Dans un mode de réalisation préféré, lesdites particules présentent des caractéristiques aérodynamiques qui permettent une distribution ciblée d'épinéphrine sur le ou les sites d'action.

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