Inhalation particles

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/72 (2006.01) A61K 9/14 (2006.01) A61K 31/573 (2006.01) A61K 45/00 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) B01J 2/04 (2006.01)

Patent

CA 2395881

A method for preparing particles suitable for pulmonary drug delivery by inhalation, and inhalation compositions comprising such particles are provided. The method comprises providing a liquid feed stock comprising one or several active agents, atomising the liquid feed stock, suspending the droplets in a carrier gas, and passing the carrier gas and droplets through a heated tube flow reactor under predetermined residence time and temperature history, and collecting the particles produced. Fine uniform crystalline spherical uncharged particles with narrow aerodynamic particle size distribution between about 1 to 5 µm and rough surfaces, are obtained. The particles show improved dispersibility and stability.

L'invention concerne un procédé pour préparer des particules aptes à la libération de médicament pour les poumons par inhalation, et des compositions pour inhalation comprenant de tells particules. Ledit procédé comprend la fourniture d'une matière première liquide contenant un ou plusieurs agents actifs ; l'atomisation de la matière première liquide ; la mise en suspension des gouttelettes dans un gaz vecteur ; l'acheminement du gaz vecteur et des gouttelettes à travers un réacteur d'écoulement à tube chauffé en tenant compte d'un temps de séjour et d'un suivi thermique prédéterminés ; le captage des particules produites. On obtient de fines particules uniformes cristallines et sphériques, exemptes de charges, à répartition granulométrique aérodynamique étroite allant d'environ 1 à 5 mu m et dont la surface est rugueuse. Ces particules présentent une dispersabilité et une stabilité améliorées.

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