C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C07K 14/81 (2006.01) C12N 15/09 (2006.01) C12N 15/67 (2006.01) C12N 15/85 (2006.01) C12P 1/00 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2452005
The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell such that programmed cell death in the cell is prevented or delayed. The present invention also relates to increasing production of a cell-related product by expressing one or more anti-apoptotic polypeptides in a cell such that production of the cell-related product by the cell is increased. Recombinant cells useful for producing cell-related product or cellular therapy are also provided.
L'invention concerne la possibilité de prévenir ou de différer la mort cellulaire programmée, par l'expression d'un ou plusieurs polypeptides anti-apoptose dans une cellule, ce qui permet de prévenir ou de différer la mort cellulaire dans la cellule. L'invention concerne également la possibilité d'augmenter la production d'un produit lié à la cellule, par l'expression d'un ou plusieurs polypeptides anti-apoptose dans une cellule, ce qui permet d'augmenter la production du produit considéré par la cellule. L'invention concerne également des cellules de recombinaison utiles pour la production du produit susmentionné ou pour la conduite d'une thérapie cellulaire.
Ailor Eric
Betenbaugh Michael J.
Figueroa Bruno Jr.
Hardwick Marie
Reff Mitchell
Biogen Idec Inc.
Fetherstonhaugh & Co.
Idec Pharmaceutical Corporation
Johns Hopkins University
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