A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) G01N 33/574 (2006.01) C07K 16/30 (2006.01)
Patent
CA 2646127
Disclosed is a method for inhibiting the growth of breast carcinoma stem cells, that express High Molecular Weight-Melanoma Associated Antigen (HMW-MAA). The method comprises administering to an individual a composition comprising an antibody reactive with HMW-MAA or a fragment of such an antibody in an amount effective to inhibit the growth of the breast carcinoma cells. Also provided are methods for inhibiting metastasis of breast carcinomas and methods for identifying HMW-MAA+ breast cancer stem cells.
L'invention concerne un procédé permettant d'inhiber la croissance de cellules souches du cancer du sein exprimant l'antigène de poids moléculaire élevé associé au mélanome (HMW-MAA). Ce procédé comprend l'administration à un individu d'une composition comprenant un anticorps ou fragment d'anticorps réactif vis-à-vis du HMW-MAA en une quantité efficace pour inhiber la croissance des cellules du cancer du sein. L'invention concerne également des procédés permettant d'inhiber la métastase des cancers du sein ainsi que des procédés d'identification de cellules souches du cancer du sein positives pour le HMW-MAA.
Clay Tim
Devi Gay
Ferrone Soldano
Lyerly H. Kim
Morse Michael A.
Duke University
Health Research Inc.
Ridout & Maybee Llp
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