Inhibition of raf kinase using quinolyl, isoquinolyl or...

Details Inhibition of raf kinase using quinolyl, isoquinolyl or... Inhibition of raf kinase using quinolyl, isoquinolyl or...

C - Chemistry, Metallurgy

07

D

C07D 213/40 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61P 43/00 (2006.01) C07D 215/38 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2443950

This invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in such therapy. These compounds have one of the following formulae: A D B (I) A'-D-B' (II) A"~D~B" (III) wherein D is -NH-C (O)-NH-; A is a substituted pyridyl group; A' is an optionally substituted isoquinolinyl group or a quinolinyl group; A" is a substituted quinolinyl group, B and B' are each, independently, a substituted or unsubstituted bridged cyclic structure of up to 30 carbon atoms; and a cyclic moiety having at least 5 members and B" is a substituted or unsubstituted, up to tricyclic aryl or heteroaryl moiety of up to 30 carbon atoms.

La présente invention concerne un groupe d'urées de quinolyl, d'isoquinolyl et de pyridyl, leur utilisation dans le traitement de maladies induites par raf, ainsi que des compositions pharmaceutiques renfermant ces urées, destinées à être utilisées dans de telles thérapies.

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