C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/54 (2006.01) A61K 31/42 (2006.01) A61K 31/426 (2006.01) A61P 3/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 19/10 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) C07D 263/48 (2006.01)
Patent
CA 2568186
The present invention relates to compounds with the formula (I), (II), (III) or (IV): (I) (II), (III), or (IV), wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-.beta.-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11- .beta.-hydroxysteroid dehydrogenase type 1 enzyme.
La présente invention concerne des composés représentés par les formules (I), (II), (III) ou (IV): (I) (II), (III), ou (IV), dans lesquelles R1, R2, R3, R4, R5, R6, R7, X et Z sont tels que définis dans les spécifications et, des compositions pharmaceutiques comprenant ces composés ainsi que des techniques d'utilisation de ces composés pour le traitement de troubles associés à la déshydrogenase11-?-hydroxysteroïde humaine et pour la préparation d'un médicament qui agit sur l'enzyme déshydrogenase11-?-hydroxysteroïde humaine de type I.
Bartberger Michael D.
Bercot Eric A.
Cai Guolin
Fotsch Christopher H.
Frizzle Matthew J.
Amgen Inc.
Biovitrum Ab
Goudreau Gage Dubuc
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